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KMID : 0603820130190030195
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Journal of Experimental & Biomedical Science
2013 Volume.19 No. 3 p.195 ~ p.205
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The Ameliorative Effects of Korean Bean-Leaves on Inflammation and Liver Injury in Obese Rat Model
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Jin Byung-Moon
Choi Seok-Cheol
Lee Hye-Sook
Jung Sang-Bong
Hyun Kyung-Yae
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Abstract
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Obesity may cause metabolic syndrome and adult diseases. This study was undertaken to investigate the ameliorative or useful effects of beanleaves on inflammation and liver damage in obese rat models. Rats were divided into three groups: a control group (normal diet, n=6), a fat diet group (45%-fat diet, n=7), and a bean leaf group (45%-fat+Korean bean leaves diet, n=7). Body weights in the bean leaf group were lower than those of the fat group (P<0.05). Serum tumor necrosis factor-α (TNF-α) and prostaglandin E₂ (PGE₂) concentrations were lower in both the control and bean leaf groups than in the fat group (P<0.001). TNF-α concentrations in the bean leaf group were slightly higher than in the control group but statistically significant (P<0.05). The bean leaf group histologically exhibited lower fatty degeneration, spotty necrosis, and leukocyte infiltrations in hepatic tissues than those of the fat group. In the homogenized liver tissues, the cyclooxygenase-2 (COX-2) gene was only expressed in the fat group. The gene expression levels of hepatic TNF-α, inducible nitric-oxide synthase, peroxiome proliferator-activated receptor-α (PPAR-α), poly (ADP-ribose) polymerase (PARP), and transforming growth factor-β1 (TGF-β1) were weaker in the bean leaf group than in the fat group. These results suggest that adding bean-leaves to the diet may ameliorate obesity-induced systemic inflammation and liver damage and that bean leaves may be a useful food for preventing obesity and thereby metabolic syndrome and adult diseases
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KEYWORD
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Obesity, Bean-leaves, Liver, Inflammation, Fatty liver, COX-2, iNOS, PPAR-α, PARP, TGF-β1
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